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Neonatal seizures are the most common manifestation of neurological illness in the newborn, yet their accurate diagnosis and management remain challenging. This is particularly true in resource-limited settings.  In this symposium, members of two International League Against Epilepsy (ILAE) task forces on classification, diagnosis and treatment of neonatal seizures presented a novel, evidence-based framework for the diagnosis and classification of neonatal seizures that integrates clinical signs and electroencephalographic findings to specify varying levels of diagnostic certainty. The wide spectrum of neonatal seizures are illustrated, as well as common management challenges, and practical evidence-based management strategies that can be tailored to a wide range of practice settings.


infant newborn neonate seizure hypoxic-ischemic encephalopathy electroencephalography anticonvulsants

Article Details

Author Biographies

Amanda G. Sandoval Karamian, MD, Children's Hospital of Philadelphia

Children’s Hospital of Philadelphia

Division of Neurology

Philadelphia, PA

Ronit Pressler, MD, PhD, MRCPCH, Great Ormond Street Hospital for Children

Consultant in Clinical Neurophysiology

Great Ormond Street Hospital for Children

London, UK

Cecil D. Hahn, MD, MPH, The Hospital for Sick Children

Division of Neurology, The Hospital for Sick Children

Department of Paediatrics, University of Toronto

Toronto, Canada

Hans Hartmann, MD, Hanover Medical School

Clinic for Pediatric Kidney, Liver and Metabolic Disorders

Hannover Medical School

Hannover, Germany

Jo Wilmshurst, MBBS, MD, University of Cape Town

Department of Paediatric Neurology, Red Cross War Memorial Children’s Hospital

Neuroscience Institute, University of Cape Town, South Africa

Courtney J. Wusthoff, MD, MS, Stanford Children's Health

Stanford Child Neurology

Palo Alto, CA 

How to Cite
Sandoval Karamian, A., Pressler, R., Hahn, C., Hartmann, H., Wilmshurst, J., & Wusthoff, C. (2022). Neonatal Seizures: Practical Approaches to Classification, Diagnosis and Management. Journal of the International Child Neurology Association, 1(1).


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