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The advancement in medical knowledge could have not been possible without interlocking and reinforcing the bedside-lab continuum. In the field of pediatric neurology, one of the best illustrative examples is our quest for finding neuroprotective therapies in the setting of neonatal hypoxic-ischemic encephalopathy. In this review, we discuss the careful clinical observations driven from the bedside dating back to the work of Frank Ford. We trace the relentless efforts to emulate the pathogenesis in animal models to testing potential therapies in clinical trials that made the transfer of this knowledge back to the bedside possible in order to save and improve the quality of life for hundred of thousands of newborns who suffered hypoxic ischemic insult.


Neuroprotection hypoxic-ischemic injury neuroplasticity inflammation repair term and preterm infants encephalopathy glutamate excitotoxicity.

Article Details

Author Biographies

Fatima Yousif Ismail, Clinical and research Fellow, Department of Pediatrics, Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Maryland, USA. Teaching Assistant, Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University.

Department of Pediatrics, Neurology and Developmental Medicine, Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Maryland, USA.

Department of Pediatrics, College of Medicine and Health  Sciences, United Arab Emirates University

Ali Fatemi

Departments of Neurology and Pediatrics, Kennedy Krieger Institute and Johns Hopkins University, School of Medicine, Maryland, USA.

Michael Johnston, Kennedy Krieger Institute and Johns Hopkins University School of Medicine

Professor of Neurology, Pediatrics and PM&R, Kennedy Krieger Institute and Johns Hopkins University, School of Medicine, Maryland, US.
How to Cite
Ismail, F. Y., Fatemi, A., & Johnston, M. (2017). The Quest for Neuroprotection for Injuries in the Developing Brain. Journal of the International Child Neurology Association, 1(1).


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