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Autism spectrum disorder stem cell therapy trials Neurorestoration medical tourism

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Author Biography

Pauline Samia, Department of Paediatrics and Child Health, Medical College, Aga Khan University, Nairobi, Kenya

Dr Pauline Samia is an Assistant Professor at the Department of Paediatrics and Child Health at Aga Khan University, Kenya.

How to Cite
Patel, A. A. ., Samia, P., Singhi, P., Kirton, A., Hegde, A., Dale, R., Idro, R., Cross, H., Tein, I., Topaloglu, H. ., & Wilmshurst, J. (2023). Position statement from the Advocacy Committee of the ICNA; Stem Cell Therapies in Autism Spectrum Disorders: Stem Cell Therapies in Autism Spectrum Disorders. Journal of the International Child Neurology Association, 1(1).


  1. Hodges H, Fealko C, Soares N. Autism spectrum disorder:definition, epidemiology, causes, and clinical evaluation. Translational Pediatrics. 2020;9(S1):S55–S65. PubMed.
  2. Larijani B, Foroughi Heravani N, Alavi-Moghadam S, Goodarzi P, Rezaei-Tavirani M, Payab M, et al. Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions. In: Cell Biology and Translational Medicine, Volume 13. Springer International Publishing; 2020. p. 107–124. PubMed.
  3. Pistollato F, Forbes-Hernández TY, Calderón Iglesias R,Ruiz R, Elexpuru Zabaleta M, Cianciosi D, et al. Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies. Pharmacological Research. 2020;152:1-72. PubMed.
  4. Sivanesan S, Tan A, Jeyaraj R, Lam J, Gole M, Hardan A, et al. Pharmaceuticals and Stem Cells in Autism Spectrum Disorders: Wishful Thinking? World Neurosurgery.2017;98:659–672. PubMed.
  5. Siniscalco D, Kannan S, Semprún-Hernández N, Eshraghi AA, Brigida AL, Antonucci N. Stem cell therapy in autism: recent insights. Stem Cells and Cloning: Advances and Applications. 2018;Volume 11:55–67. PubMed.
  6. Paulson A, Vargus-Adams J. Overview of Four Functional Classification Systems Commonly Used in Cerebral Palsy. Children. 2017;4(4):30. PubMed.
  7. Eggenberger S, Boucard C, Schoeberlein A, Guzman R, Limacher A, Surbek D, et al. Stem cell treatment and cerebral
  8. palsy: Systemic review and meta-analysis. World Journal of Stem Cells. 2019;11(10):891–903. PubMed.
  9. Kiasatdolatabadi A, Lotfibakhshaiesh N, Yazdankhah M, Ebrahimi-Barough S, Jafarabadi M, Ai A, et al. The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review. Molecular Neurobiology. 2016;54(7):4963–4972. PubMed.
  10. Nehme R, Barrett LE. Using human pluripotent stem cell models to study autism in the era of big data. Molecular Autism. 2020;11(1). PubMed.
  11. Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, et al. Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism. Behavioural Brain Research. 2017;331:254–260. PubMed.
  12. Novak I, Walker K, Hunt RW, Wallace EM, Fahey M, Badawi N. Concise Review: Stem Cell Interventions
  13. for People With Cerebral Palsy: Systematic Review With Meta-Analysis. Stem Cells Translational Medicine. 2016;5(8):1014–1025. PubMed.
  14. Bradstreet JJ, Sych N, Antonucci N, Klunnik M, Ivankova O, Matyashchuk I, et al. Efficacy of fetal stem cell transplantation in autism spectrum disorders: an open-labeled pilot study. Cell Transplantation. 2014;23(Suppl 1):105-12. PubMed.
  15. Dawson G, Sun JM, Davlantis KS, Murias M, Franz L, Troy J, et al. Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. Stem Cells Translational Medicine. 2017;6(5):1332–1339. PubMed.
  16. Chez M, Lepage C, Parise C, Dang-Chu A, Hankins A, Carroll M. Safety and Observations from a Placebo-Controlled, Crossover Study to Assess Use of Autologous Umbilical Cord Blood Stem Cells to Improve Symptoms in Children with Autism. Stem Cells Translational Medicine. 2018;7(4):333–341. PubMed.
  17. Riordan NH, Hincapié ML, Morales I, Fernández G, Allen N, Leu C, et al. Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels. Stem Cells Translational Medicine.
  18. ;8(10):1008–1016. PubMed.
  19. Liu J, Lv ZY, Li Y. Progress in clinical trials of stem cell therapy for cerebral palsy. Neural Regeneration Research. 2021;16(7):1377. PubMed.
  20. Sun JM, Kurtzberg J. Stem cell therapies in cerebral palsy and autism spectrum disorder. Developmental Medicine Child Neurology. 2021;63(5):503–510. PubMed.
  21. Vankeshwaram V, Maheshwary A, Mohite D, Omole JA, Khan S. Is Stem Cell Therapy the New Savior for Cerebral Palsy Patients? A Review. Cureus. 2020:e10214. PubMed.
  22. Xie B, Chen M, Hu R, Han W, Ding S. Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials. Stem Cells International. 2020;2020:1–10. PubMed.
  23. Feustel AC, MacPherson A, Fergusson DA, Kieburtz K, Kimmelman J. Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease. Neurology. 2020;94(1). PubMed.
  24. Huang H, Young W, Chen L, Feng S, Zoubi ZMA, Sharma HS, et al. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017). Cell Transplantation. 2018;27(2):310–324. PubMed.
  25. Rezak M, de Carvalho M. Disease modification in neurodegenerative diseases: Not quite there yet. Neurology. 2020;94(1):12–13. PubMed.
  26. Petersen A, Seear K, Munsie M. Therapeutic journeys: the hopeful travails of stem cell tourists. Sociology of Health & Illness. 2013;36(5):670–685. PubMed.
  27. Master Z, Resnik DB. Stem-cell tourism and scientific responsibility: Stem-cell researchers are in a unique position to curb the problem of stem-cell tourism. EMBO reports. 2011;12(10):992–995. PubMed.
  28. Sharpe K, Di Pietro N, Jacob KJ, Illes J. A Dichotomy of Information-Seeking and Information-Trusting: Stem Cell Interventions and Children with Neurodevelopmental Disorders. Stem Cell Reviews and Reports. 2016;12(4):438–447. PubMed.

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