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Epilepsies are disorders associated with the dysfunction of the integrity of brain neural networks, leading to changes in physiological interactions and the possible emergence of pathological neural networks. Numerous mechanisms may be associated with alterations in neural networks in epilepsy, including the recurrence of abnormal synchronous neuronal activity during seizures or interictal discharges. The underlying etiology, stage of neurodevelopment in which they occur, and the use of antiseizure medication must also play a significant role in these abnormalities. Additionally, neural network alterations in epilepsy may have a significant relationship with the clinical phenotype, contributing to the unsatisfactory response to pharmacological treatment, as well as the frequent occurrence of neuropsychiatric comorbidities in these disorders. This review presents data on changes in structural and functional brain networks in epilepsies, their relation to specific phenotypes, and their potential impact on the neurodevelopment of children and adolescents.


neural network neurodevelopment comorbidities

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Coan, A. C. (2023). The impact of epilepsies on brain structure and function. Journal of the International Child Neurology Association, 1(1).

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