Article Sidebar

Submitted
September 26, 2019
Accepted
April 15, 2020
Published
June 21, 2020
Download
PDF
Statistic
Read Counter : 445 Download : 180

Downloads

Download data is not yet available.

Main Article Content

Abstract

Our report is intended to analyze the specificity of certain magnetic resonance patterns that occur in imaging of neuronal-glial tumors associated with epilepsy in children.

Materials and methods: 33 children suffered from neuronal-glial tumors associated with symptomatic epilepsy (aged from 5 months to 17 years) were examined and treated within 2007-2017 years; prospective follow-up lasted from 1 to 8 years. MRI was performed by means of an apparatus with magnetic field induction of 1.5 and 3.0 Tesla before and after surgery. High resolution MRI (MRI HR) scan was applied in accordance with the epileptic scanning protocol. Anesthesia included methods of sevoflurane sedation.

Results: Dysembryoplastic neuroepithelial tumors (DNETs) confirmed histopathologically were revealed in 18 children; gangliogliomas (GGs) were revealed in 15 children. Histological analysis revealed the evidence of both DNET and GG in one tumor site in 2 patients. Six patients showed histopathologically confirmed dual pathology and focal cortical dysplasia FCD IIIb.

Verification of the neoplastic process on MRI results was complicated in 12 patients. Twenty one (21) patients showed the specific signs of tumors to be of neuronal-glial origin as described in literature; a cortical localization, a “triangular” shape, a “comet tail” symptom, and a “soup bubble” pattern.

Based on tractography (DTI) and fractionally anisotropy (FA) the paths displacement without the distraction of fibers integrity was observed in 4 patients with DNET and 2 patients with GG.

Peritumoral hyperintensity of the signal, the abnormality of gray-white differentiation and cortical organization let us suggest combination with dual pathology in 9 patients.

One case of DNET and four cases of GGs turned out to be contract positive. The localization was predominantly temporal. Reliable signs of a neoplastic process in the differential diagnosis were contrast enhancement and continued growth manifested in the adjacent bone tissue remodeling. However, in some cases, differentiation of DNETs / GGs /FCD IIb having a number of similar MRI signs was not possible until a histological diagnosis was made.

Keywords

neuronal-glial tumors drug-resistant epilepsy neuroimaging

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Khalilov, V., Kholin, A., Zavadenko, N., Medvedeva, N., & Gazdieva, K. (2020). Neuroimaging patterns of neuronal-glial tumors associated with focal epilepsy in children. Journal of the International Child Neurology Association, 1(1). https://doi.org/10.17724/jicna.2020.119
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. García-Fernández M, Fournier-Del Castillo C, Ugalde-Canitrot A, Pérez-Jiménez Á, Álvarez-Linera J, De Prada-Vicente I | display-authors=etal (2011) Epilepsy surgery in children with developmental tumours. Seizure 20 (8):616-27. DOI: 10.1016/j.seizure.2011.06.003 PMID: 21741275.
  2. Fernandez C, Girard N, Paz Paredes A, Bouvier-Labit C, Lena G, Figarella-Branger D (2003) The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases. AJNR Am J Neuroradiol 24 (5):829-34. PMID: 12748079.
  3. Stepanenko AIu, Arkhipova NA, Shishkina LV, Pronin IN, Lubnin AIu, Buklina SB (2008) [Surgical tactics for the treatment of symptomatic temporal lobe epilepsy]. Zh Vopr Neirokhir Im N N Burdenko (1):17-22. PMID: 18488891.
  4. Urbach H (2008) MRI of long-term epilepsy-associated tumors. Semin Ultrasound CT MR 29 (1):40-6. DOI: 10.1053/j.sult.2007.11.006 PMID: 18383906.
  5. Khalilov VS, Kholin AA, Medvedeva NA, Rasskazchikova IV, Bobylova MY, Zavadenko NN (2017) [The use of low-field MRI for visualization of epileptogenic brain lesions in children]. Zh Nevrol Psikhiatr Im S S Korsakova 117 (11):84-90. DOI: 10.17116/jnevro201711711184-90 PMID: 29265092.
  6. Khalilov V.S., Kholin A.A., Kostylev F.A., Balyulin Yu.V., Gubachikova F.A., Gazdieva Kh.Sh. Specific MRI-patterns of neuronal-glial tumors associated with focal epilepsy in children. Radiological Diagnostics and Therapy 2017; 2(8): 63-64. (in Russ.)
  7. Prayson RA, Napekoski KM (2012) Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. Hum Pathol 43 (7):1113-8. DOI: 10.1016/j.humpath.2011.08.023 PMID: 22221701.
  8. Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A | display-authors=etal (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia 52 (1):158-74. DOI: 10.1111/j.1528-1167.2010.02777.x PMID: 21219302.
  9. Phi JH, Kim SK, Cho BK, Lee SY, Park SY, Park SJ | display-authors=etal (2009) Long-term surgical outcomes of temporal lobe epilepsy associated with low-grade brain tumors. Cancer 115 (24):5771-9. DOI: 10.1002/cncr.24666 PMID: 19806640.
  10. Koeller KK, Henry JM (2001) From the archives of the AFIP: superficial gliomas: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics 21 (6):1533-56. DOI: 10.1148/radiographics.21.6.g01nv051533 PMID: 11706224.
  11. Khalilov VS, Kholin AA, Medvedeva NA, Vasiliev IG, Rasskazchikova IV, Ismailova RR | display-authors=etal (2016) [MRI-characteristics of epileptogenic supratentorial brain tumors in children]. Zh Nevrol Psikhiatr Im S S Korsakova 116 (1):56-63. DOI: 10.17116/jnevro20161161156-63 PMID: 26977627.
  12. Daumas-Duport C, Varlet P, Bacha S, Beuvon F, Cervera-Pierot P, Chodkiewicz JP (1999) Dysembryoplastic neuroepithelial tumors: nonspecific histological forms -- a study of 40 cases. J Neurooncol 41 (3):267-80. DOI: 10.1023/a:1006193018140 PMID: 10359147.
  13. Suh YL (2015) Dysembryoplastic Neuroepithelial Tumors. J Pathol Transl Med 49 (6):438-49. DOI: 10.4132/jptm.2015.10.05 PMID: 26493957.
  14. Lee DY, Chung CK, Hwang YS, Choe G, Chi JG, Kim HJ | display-authors=etal (2000) Dysembryoplastic neuroepithelial tumor: radiological findings (including PET, SPECT, and MRS) and surgical strategy. J Neurooncol 47 (2):167-74. DOI: 10.1023/a:1006401305247 PMID: 10982159.
  15. Paudel K, Borofsky S, Jones RV, Levy LM (2013) Dysembryoplastic neuroepithelial tumor with atypical presentation: MRI and diffusion tensor characteristics. J Radiol Case Rep 7 (11):7-14. DOI: 10.3941/jrcr.v7i11.1559 PMID: 24421925.
  16. Kabat J, Król P (2012) Focal cortical dysplasia - review. Pol J Radiol 77 (2):35-43. DOI: 10.12659/pjr.882968 PMID: 22844307.
  17. Parmar HA, Hawkins C, Ozelame R, Chuang S, Rutka J, Blaser S (2007) Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors. J Comput Assist Tomogr 31 (3):348-53. DOI: 10.1097/01.rct.0000243453.33610.9d PMID: 17538277.
  18. Mukhin K.Yu. FOCAL CORTICAL DYSPLASIAS: CLINICAL AND ELECTRO-NEUROIMAGING CHARACTERISTICS. Russian Journal of Child Neurology. 2016;11(2):8-24. (In Russ.) https://doi.org/10.17650/2073-8803-2016-11-2-8-24
  19. Yen PS, Teo BT, Chiu CH, Chen SC, Chiu TL, Su CF (2009) White Matter tract involvement in brain tumors: a diffusion tensor imaging analysis. Surg Neurol 72 (5):464-9; discussion 469. DOI: 10.1016/j.surneu.2009.05.008 PMID: 19608227.
  20. Wei CW, Guo G, Mikulis DJ (2007) Tumor effects on cerebral white matter as characterized by diffusion tensor tractography. Can J Neurol Sci 34 (1):62-8. DOI: 10.1017/s0317167100005801 PMID: 17352349.
  21. Alikhanov A.A., Ryzhkov B.N., Demushkina A.A. Vizualization of dysplastic brain substrates in epileptic children. Neurosurgery and neurology of childhood. 2010; 1(23): 27-38. (In Russ.)
  22. Frater JL, Prayson RA, Morris III HH, Bingaman WE (2000) Surgical pathologic findings of extratemporal-based intractable epilepsy: a study of 133 consecutive resections. Arch Pathol Lab Med 124 (4):545-9. DOI: 10.5858/2000-124-0545-SPFOEB PMID: 10747311.