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Abstract
Children in low and middle income countries are 16 times more likely to die before 5 years of age compared to children in high-income countries. More than 200 million children under five in the developing world do not fulfil their potential, the major reasons appear to be poor nutrition, and limited access to education in the setting of extreme poverty. Three major factors with multiple sub-headings result in threats to the child’s brain. Namely, the background setting the child is born into and grows up in, the acquired influences of the local setting, and the available interventions for the child. The following text is an overview of these key issues and their subheadings, for children residing in low and middle income countries. Whilst many influencers are beyond the control of health practitioners, such as conflicts of war and impact of famine, there are relatively cost effective interventions which can have a massive ripple effect in reducing diseases of high burden such as effective vaccination programs, insectide immerced nets for beds, and effective pigs pens. There is need for viable protocols to be adapted for the local setting, for simple, cost effective diagnostic tools to be developed and for health practitioners to be equipped with the skills to cope with neurological disorders, especially those prevalent in and specific to low and middle income countries.
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References
1. World Health O. World Health Statistics. 2013. A wealth of information of global public health. 2013. http://apps.who.int/iris/bitstream/10665/82058/1/WHO_HIS_HSI_13.1_eng.pdf accessed April 2016
2. Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369(9555):60-70.
3. Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013;131(3):e755-63.
4. The World Health O. Global Health Observatory Data Repository. 2012. http://apps.who.int/ghodata/?theme=country accessed April 2016
5. Fottrell E, Osrin D, Alcock G, Azad K, Bapat U, Beard J, et al. Cause-specific neonatal mortality: analysis of 3772 neonatal deaths in Nepal, Bangladesh, Malawi and India. Arch Dis Child Fetal Neonatal Ed. 2015;100(5):F439-47.
6. Sialubanje C, Massar K, van der Pijl MS, Kirch EM, Hamer DH, Ruiter RA. Improving access to skilled facility-based delivery services: Women's beliefs on facilitators and barriers to the utilisation of maternity waiting homes in rural Zambia. Reprod Health. 2015;12:61.
7. Tshala-Katumbay D, Mwanza JC, Rohlman DS, Maestre G, Oriá RB. A global perspective on the influence of environmental exposures on the nervous system. Nature. 2015;527(7578):S187-92.
8. Sumner A. Global Poverty and the New Bottom Billion: What if Three-Quarters of the World’s Poor Live in Middle-Income Countries? Institute of Develop Studies. 2010;2010(349):41.
9. Chin-Lun Hung G, Hahn J, Alamiri B, Buka SL, Goldstein JM, Laird N, et al. Socioeconomic disadvantage and neural development from infancy through early childhood. Int J Epidemiol. 2015;44(6):1889-99.
10. Bank. W. Global Monitoring Report 2014/2015: Ending Poverty and Sharing Prosperity. 2015 [cited 2016 03/02/2016]. 1st edition:[A joint publication of the World Bank and the International Monetary Fund].
11. Lang V, Lingnau H. Defining and measuring poverty and inequality post-2015. Journal of International Development. 2015;27:15.
12. Björklund G. Workshop 4 (synthesis): securing food production under climate variability--exploring the options. Water Sci Technol. 2004;49(7):147-9.
13. Haile M. Weather patterns, food security and humanitarian response in sub-Saharan Africa. Philos Trans R Soc Lond B Biol Sci. 2005;360(1463):2169-82.
14. Kim KH, Kabir E, Ara Jahan S. A review of the consequences of global climate change on human health. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(3):299-318.
15. Rieder M, Choonara I. Armed conflict and child health. Arch Dis Child. 2012;97(1):59-62.
16. Banea M, Tylleskär T, Rosling H. Konzo and Ebola in Bandundu region of Zaire. Lancet. 1997;349(9052):621.
17. Elston JW, Moosa AJ, Moses F, Walker G, Dotta N, Waldman RJ, et al. Impact of the Ebola outbreak on health systems and population health in Sierra Leone. J Public Health (Oxf). 2015.
18. Musisi S, Kinyanda E. Emotional and behavioural disorders in HIV seropositive adolescents in urban Uganda. East African medical journal. 2009;86(1):16-24.
19. Van Rie A, Mupuala A, Dow A. Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo. Pediatrics. 2008;122(1):e123-8.
20. Scheffer IE. Epilepsy genetics revolutionizes clinical practice. Neuropediatrics. 2014;45(2):70-4.
21. Guerrant RL, DeBoer MD, Moore SR, Scharf RJ, Lima AA. The impoverished gut--a triple burden of diarrhoea, stunting and chronic disease. Nat Rev Gastroenterol Hepatol. 2013;10(4):220-9.
22. Fischer Walker CL, Lamberti L, Adair L, Guerrant RL, Lescano AG, Martorell R, et al. Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway? PLoS One. 2012;7(10):e47908.
23. Richard SA, Black RE, Gilman RH, Guerrant RL, Kang G, Lanata CF, et al. Catch-up growth occurs after diarrhea in early childhood. J Nutr. 2014;144(6):965-71.
24. Collins SM, Surette M, Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735-42.
25. Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH. Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann Neurol. 2011;69(2):240-7.
26. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451-63.
27. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-30.
28. Guerrant RL, Kosek M, Moore S, Lorntz B, Brantley R, Lima AA. Magnitude and impact of diarrheal diseases. Arch Med Res. 2002;33(4):351-5.
29. Guerrant RL, Oriá RB, Moore SR, Oriá MO, Lima AA. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev. 2008;66(9):487-505.
30. Petri WA, Miller M, Binder HJ, Levine MM, Dillingham R, Guerrant RL. Enteric infections, diarrhea, and their impact on function and development. J Clin Invest. 2008;118(4):1277-90.
31. Kisby GE, Spencer PS. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? Int J Environ Res Public Health. 2011;8(10):3889-921.
32. Marler TE, Lindström AJ. Free sugar profile in cycads. Front Plant Sci. 2014;5:526.
33. Sarmento A, Barros L, Fernandes Â, Carvalho AM, Ferreira IC. Valorization of traditional foods: nutritional and bioactive properties of Cicer arietinum L. and Lathyrus sativus L. pulses. J Sci Food Agric. 2015;95(1):179-85.
34. Spencer PS, Schaumburg HH. Lathyrism: a neurotoxic disease. Neurobehav Toxicol Teratol. 1983;5(6):625-9.
35. Tshala-Katumbay D, Mumba N, Okitundu L, Kazadi K, Banea M, Tylleskär T, et al. Cassava food toxins, konzo disease, and neurodegeneration in sub-Sahara Africans. Neurology. 2013;80(10):949-51.
36. Wang W, Feng B, Xiao J, Xia Z, Zhou X, Li P, et al. Cassava genome from a wild ancestor to cultivated varieties. Nat Commun. 2014;5:5110.
37. Banea JP, Bradbury JH, Mandombi C, Nahimana D, Denton IC, Kuwa N, et al. Effectiveness of wetting method for control of konzo and reduction of cyanide poisoning by removal of cyanogens from cassava flour. Food Nutr Bull. 2014;35(1):28-32.
38. Ciglenečki I, Eyema R, Kabanda C, Taafo F, Mekaoui H, Urbaniak V. Konzo outbreak among refugees from Central African Republic in Eastern region, Cameroon. Food Chem Toxicol. 2011;49(3):579-82.
39. Cliff J, Nicala D, Saute F, Givragy R, Azambuja G, Taela A, et al. Konzo associated with war in Mozambique. Trop Med Int Health. 1997;2(11):1068-74.
40. Nzwalo H, Cliff J. Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease. PLoS Negl Trop Dis. 2011;5(6):e1051.
41. Okitundu Luwa E-Andjafono D, Bumoko Makila-Mabe G, Ayanne MT, Kikandau JK, Mashukano N, Kazadi Kayembe T, et al. [Persistence of konzo epidemics in Kahemba, Democratic Republic of Congo: phenomenological and socio-economic aspects]. Pan Afr Med J. 2014;18:213.
42. Oluwole OS, Onabolu AO, Link H, Rosling H. Persistence of tropical ataxic neuropathy in a Nigerian community. J Neurol Neurosurg Psychiatry. 2000;69(1):96-101.
43. Tylleskär T, Légué FD, Peterson S, Kpizingui E, Stecker P. Konzo in the Central African Republic. Neurology. 1994;44(5):959-61.
44. Tekle-Haimanot R, Forsgren L, Abebe M, Gebre-Mariam A, Heijbel J, Holmgren G, et al. Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a community-based study. Epilepsy Res. 1990;7(3):230-9.
45. Ludolph AC, Hugon J, Dwivedi MP, Schaumburg HH, Spencer PS. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain. 1987;110 ( Pt 1):149-65.
46. Ngudi DD, Kuo YH, Van Montagu M, Lambein F. Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010. PLoS Negl Trop Dis. 2012;6(7):e1759.
47. Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, et al. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genet Epigenet. 2014;6:37-44.
48. Bale TL. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues Clin Neurosci. 2014;16(3):297-305.
49. Maestre G, Ottman R, Stern Y, Gurland B, Chun M, Tang MX, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol. 1995;37(2):254-9.
50. Oriá RB, Patrick PD, Oriá MO, Lorntz B, Thompson MR, Azevedo OG, et al. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz J Med Biol Res. 2010;43(3):249-56.
51. Jackson PB, Boccuto L, Skinner C, Collins JS, Neri G, Gurrieri F, et al. Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. Autism Res. 2009;2(4):232-6.
52. Peng Y, Huentelman M, Smith C, Qiu S. MET receptor tyrosine kinase as an autism genetic risk factor. Int Rev Neurobiol. 2013;113:135-65.
53. Bihaqi SW, Bahmani A, Adem A, Zawia NH. Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD. Neurotoxicology. 2014;44:114-20.
54. Collotta M, Bertazzi PA, Bollati V. Epigenetics and pesticides. Toxicology. 2013;307:35-41.
55. Dosunmu R, Alashwal H, Zawia NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech Ageing Dev. 2012;133(6):435-43.
56. Wang G, Chen Z, Bartell T, Wang X. Early Life Origins of Metabolic Syndrome: The Role of Environmental Toxicants. Curr Environ Health Rep. 2014;1(1):78-89.
57. Goodrich JM, Basu N. Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicol In Vitro. 2012;26(4):630-5.
58. Morahan JM, Yu B, Trent RJ, Pamphlett R. Genetic susceptibility to environmental toxicants in ALS. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(7):885-90.
59. Singh S, Kumar V, Singh P, Banerjee BD, Rautela RS, Grover SS, et al. Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. Mutat Res. 2012;741(1-2):101-8.
60. Boivin MJ, Okitundu D, Makila-Mabe Bumoko G, Sombo MT, Mumba D, Tylleskar T, et al. Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava. Pediatrics. 2013;131(4):e1231-9.
61. Tshala-Katumbay D, Eeg-Olofsson KE, Kazadi-Kayembe T, Tylleskär T, Fällmar P. Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation. Muscle Nerve. 2002;25(2):230-5.
62. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197-223.
63. Silberberg D, Anand NP, Michels K, Kalaria RN. Brain and other nervous system disorders across the lifespan - global challenges and opportunities. Nature. 2015;527(7578):S151-4.
64. Salomon JA, Wang H, Freeman MK, Vos T, Flaxman AD, Lopez AD, et al. Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet. 2012;380(9859):2144-62.
65. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382(9904):1575-86.
66. Chin JH, Vora N. The global burden of neurologic diseases. Neurology. 2014;83(4):349-51.
67. Organisation TWH. The 17 neglected tropical diseases. WHO; 2014 [cited 2016 02/03/2016]. 1st edition:
68. Organisation WH. World Economic Forum and World Health Organization. From burden to ‘best buys’: reducing the economic impact of non-communicable diseases in low- and middle-Income Countries. WHO; 2011 http://www.who.int/nmh/publications/best_buys_summary/en/ [cited 2016 03/02/2016].
69. Assembly WH. Global burden of epilepsy and the need for coordinated action at the country level to address its health, social and public knowledge implications. 2015. apps.who.int/gb/ebwha/pdf_files/EB136/B136_R8-en.pdf
70. John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK. Global research priorities for infections that affect the nervous system. Nature. 2015;527(7578):S178-86.
71. Fooks AR, Banyard AC, Horton DL, Johnson N, McElhinney LM, Jackson AC. Current status of rabies and prospects for elimination. Lancet. 2014;384(9951):1389-99.
72. Labeaud AD, Bashir F, King CH. Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infections. Popul Health Metr. 2011;9(1):1.
73. McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome. J Neurol Neurosurg Psychiatry. 1997;63(3):321-6.
74. RICHTER RW, SHIMOJYO S. Neurologic sequelae of Japanese B encephalitis. Neurology. 1961;11:553-9.
75. Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The "silent" global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013;26(1):86-102.
76. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.
77. Robin S, Ramful D, Le Seach' F, Jaffar-Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric chikungunya infection. J Child Neurol. 2008;23(9):1028-35.
78. Al-Qahtani AA, Nazir N, Al-Anazi MR, Rubino S, Al-Ahdal MN. Zika virus: a new pandemic threat. J Infect Dev Ctries. 2016;10(3):201-7.
79. Chang C, Ortiz K, Ansari A, Gershwin ME. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13.
80. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016.
81. Fleming-Dutra KE, Nelson JM, Fischer M, Staples JE, Karwowski MP, Mead P, et al. Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection — United States, February 2016. Center for Disease Control and Prevention; 2016 [cited 2016 15/04/2016]. Available from: http://www.cdc.gov/mmwr/volumes/65/wr/mm6507e1.htm.
82. UNAIDS. How AIDS changed everything — MDG6: 15 years, 15 lessons of hope from the AIDS
response. 2015 [cited 2016 15/04/2016]. Available from: http://www.unaids.org/en/resources/documents/2015/MDG6_15years-15lessonsfromtheAIDSresponse.
83. Tan IL, Smith BR, von Geldern G, Mateen FJ, McArthur JC. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11(7):605-17.
84. Abubakar A, Holding P, Newton CR, van Baar A, van de Vijver FJ. The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. Developmental medicine and child neurology. 2009;51(12):968-73.
85. Wilmshurst JM, Donald KA, Eley B. Update on the key developments of the neurologic complications in children infected with HIV. Current opinion in HIV and AIDS. 2014;9(6):533-8.
86. Seale AC, Blencowe H, Zaidi A, Ganatra H, Syed S, Engmann C, et al. Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res. 2013;74 Suppl 1:73-85.
87. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatr. 2010;10:39.
88. Mehar V, Yadav D, Somani P, Bhatambare G, Mulye S, Singh K. Neonatal sepsis in a tertiary care center in central India: microbiological profile, antimicrobial sensitivity pattern and outcome. J Neonatal Perinatal Med. 2013;6(2):165-72.
89. Thwaites GE, van Toorn R, Schoeman J. Tuberculous meningitis: more questions, still too few answers. Lancet Neurol. 2013;12(10):999-1010.
90. Organization. scWH, Research. DoRHa. Global incidence and prevalence of selected curable sexually transmitted infections – 2008. 2012.
91. Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, et al. Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children. JAMA. 2007;297(20):2232-40.
92. Kihara M, Carter JA, Newton CR. The effect of Plasmodium falciparum on cognition: a systematic review. Trop Med Int Health. 2006;11(4):386-97.
93. Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K, et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet neurology. 2013.
94. Fleury A, Gomez T, Alvarez I, Meza D, Huerta M, Chavarria A, et al. High prevalence of calcified silent neurocysticercosis in a rural village of Mexico. Neuroepidemiology. 2003;22(2):139-45.
95. Ferrari TC, Moreira PR. Neuroschistosomiasis: clinical symptoms and pathogenesis. Lancet Neurol. 2011;10(9):853-64.
96. Kvalsvig J, Albonico M. Effects of geohelminth infections on neurological development. Handb Clin Neurol. 2013;114:369-79.
97. Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527(7578):S193-7.
98. Murgio A, Fernandez Milà J, Manolio A, Maurel D, Ubeda C. Minor head injury at paediatric age in Argentina. J Neurosurg Sci. 1999;43(1):15-23; discussion -4.
99. Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg. 2000;93(4):546-9.
100. Jiang JY, Xu W, Li WP, Gao GY, Bao YH, Liang YM, et al. Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. J Cereb Blood Flow Metab. 2006;26(6):771-6.
101. Liu WG, Qiu WS, Zhang Y, Wang WM, Lu F, Yang XF. Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. J Int Med Res. 2006;34(1):58-64.
102. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, et al. A year-long caregiver training program improves cognition in preschool Ugandan children with human immunodeficiency virus. J Pediatr. 2013;163(5):1409-16.e1-5.
103. Engle PL, Fernald LC, Alderman H, Behrman J, O'Gara C, Yousafzai A, et al. Strategies for reducing inequalities and improving developmental outcomes for young children in low-income and middle-income countries. Lancet. 2011;378(9799):1339-53.
104. Bangirana P, Giordani B, John CC, Page C, Opoka RO, Boivin MJ. Immediate neuropsychological and behavioral benefits of computerized cognitive rehabilitation in Ugandan pediatric cerebral malaria survivors. J Dev Behav Pediatr. 2009;30(4):310-8.
105. Boivin MJ, Busman RA, Parikh SM, Bangirana P, Page CF, Opoka RO, et al. A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV. Neuropsychology. 2010;24(5):667-73.
106. Cottler LB, Zunt J, Weiss B, Kamal AK, Vaddiparti K. Building global capacity for brain and nervous system disorders research. Nature. 2015;527(7578):S207-13.
107. Kasper J, Bajunirwe F. Brain drain in sub-Saharan Africa: contributing factors, potential remedies and the role of academic medical centres. Archives of Disease in Childhood. 2012;97(11):973-9.
108. World Health O. World health report 2006 – working together for health. 2006.
109. Department of Human Resources for Health WHO. Spotlight on health workforce statistics: Establishing and monitoring benchmarks for human resources for health:the workforce density approach. 2008.
110. Unicef. Statistics and Monitoring. 2004.
111. Wilmshurst JM, Morrow B, du Preez A, Githanga D, Kennedy N, Zar HJ. The African Pediatric Fellowship Program: Training in Africa for Africans. Pediatrics. 2016;137(1):1-12.
112. Mandeville KL, Ulaya G, Lagarde M, Gwesele L, Dzowela T, Hanson K, et al. Early career retention of Malawian medical graduates: a retrospective cohort study. Tropical medicine & international health : TM & IH. 2015;20(1):106-14.
113. Davidson LL, Grigorenko EL, Boivin MJ, Rapa E, Stein A. A focus on adolescence to reduce neurological, mental health and substance-use disability. Nature. 2015;527(7578):S161-6.
114. Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, et al. Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet. 2011;377(9783):2093-102.
115. Bank W. World Development Report 2007. Development and the Next Generation. Washington DC: 2006.
116. UNICEF. The State of the World's Children.
117. UNICEF. Ending Child Marriage: Progress and Prospects. 2012.
118. Grigorenko EL, et al. Culture and competence: Contexts of life success. Washington, DC: American Psychological Association; 2004. p. 23-53.
119. Reed RV, Fazel M, Jones L, Panter-Brick C, Stein A. Mental health of displaced and refugee children resettled in low-income and middle-income countries: risk and protective factors. Lancet. 2012;379(9812):250-65.
120. Tyrer RA, Fazel M. School and community-based interventions for refugee and asylum seeking children: a systematic review. PLoS One. 2014;9(2):e89359.
121. Ehlers CL, Criado JR. Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? Alcohol. 2010;44(1):27-37.
122. Matthews DB. Adolescence and alcohol: recent advances in understanding the impact of alcohol use during a critical developmental window. Alcohol. 2010;44(1):1-2.
123. Bhana A, Mellins CA, Petersen I, Alicea S, Myeza N, Holst H, et al. The VUKA family program: piloting a family-based psychosocial intervention to promote health and mental health among HIV infected early adolescents in South Africa. AIDS Care. 2014;26(1):1-11.
124. Ravindranath V, Dang HM, Goya RG, Mansour H, Nimgaonkar VL, Russell VA, et al. Regional research priorities in brain and nervous system disorders. Nature. 2015;527(7578):S198-206.
125. Kerac M, Postels DG, Mallewa M, Alusine Jalloh A, Voskuijl WP, Groce N, et al. The interaction of malnutrition and neurologic disability in Africa. Semin Pediatr Neurol. 2014;21(1):42-9.
126. Degenhardt L, Whiteford H, Hall WD. The Global Burden of Disease projects: what have we learned about illicit drug use and dependence and their contribution to the global burden of disease? Drug Alcohol Rev. 2014;33(1):4-12.
127. Hess AT, Jacobson SW, Jacobson JL, Molteno CD, van der Kouwe AJ, Meintjes EM. A comparison of spectral quality in magnetic resonance spectroscopy data acquired with and without a novel EPI-navigated PRESS sequence in school-aged children with fetal alcohol spectrum disorders. Metab Brain Dis. 2014;29(2):323-32.
128. Kwiatkowski MA, Roos A, Stein DJ, Thomas KG, Donald K. Effects of prenatal methamphetamine exposure: a review of cognitive and neuroimaging studies. Metab Brain Dis. 2014;29(2):245-54.
129. Ba-Diop A, Marin B, Druet-Cabanac M, Ngoungou EB, Newton CR, Preux PM. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13(10):1029-44.
130. Mustapha AF, Preux PM, Sanya EO, Akinleye CA. The prevalence and subjective handicap of epilepsy in Ilie--a rural riverine community in South West Nigeria: a door-to-door survey. Epilepsy Behav. 2014;37:258-64.
131. Osakwe C, Otte WM, Alo C. Epilepsy prevalence, potential causes and social beliefs in Ebonyi State and Benue State, Nigeria. Epilepsy Res. 2014;108(2):316-26.
132. Wagner RG, Ngugi AK, Twine R, Bottomley C, Kamuyu G, Gómez-Olivé FX, et al. Prevalence and risk factors for active convulsive epilepsy in rural northeast South Africa. Epilepsy Res. 2014;108(4):782-91.
133. Wilmshurst JM, Birbeck GL, Newton CR. Epilepsy is ubiquitous, but more devastating in the poorer regions of the world... or is it? Epilepsia. 2014.
134. Sepúlveda J, Murray C. The state of global health in 2014. Science. 2014;345(6202):1275-8.
135. Laughton B, Cornell M, Boivin M, Van Rie A. Neurodevelopment in perinatally HIV-infected children: a concern for adolescence. Journal of the International AIDS Society. 2013;16:18603.
136. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197-223.
137. Hoare J, Ransford GL, Phillips N, Amos T, Donald K, Stein DJ. Systematic review of neuroimaging studies in vertically transmitted HIV positive children and adolescents. Metabolic brain disease. 2014;29(2):221-9.
138. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10(11):e1001547.
139. Alhasnawi S, Sadik S, Rasheed M, Baban A, Al-Alak MM, Othman AY, et al. The prevalence and correlates of DSM-IV disorders in the Iraq Mental Health Survey (IMHS). World Psychiatry. 2009;8(2):97-109.
140. Espié E, Gaboulaud V, Baubet T, Casas G, Mouchenik Y, Yun O, et al. Trauma-related psychological disorders among Palestinian children and adults in Gaza and West Bank, 2005-2008. Int J Ment Health Syst. 2009;3(1):21.
141. Al-Gazali L, Hamamy H. Consanguinity and dysmorphology in Arabs. Hum Hered. 2014;77(1-4):93-107.
142. Al-Gazali L, Hamamy H, Al-Arrayad S. Genetic disorders in the Arab world. BMJ. 2006;333(7573):831-4.
143. Tadmouri GO, Al Ali MT, Al-Haj Ali S, Al Khaja N. CTGA: the database for genetic disorders in Arab populations. Nucleic Acids Res. 2006;34(Database issue):D602-6.
144. Hamdi E, Gawad T, Khoweiled A, Sidrak AE, Amer D, Mamdouh R, et al. Lifetime prevalence of alcohol and substance use in Egypt: a community survey. Subst Abus. 2013;34(2):97-104.
145. Collaborators GBoDS. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743-800.
146. Fleitlich-Bilyk B, Goodman R. Prevalence of child and adolescent psychiatric disorders in southeast Brazil. J Am Acad Child Adolesc Psychiatry. 2004;43(6):727-34.
147. Duarte C, Hoven C, Berganza C, Bordin I, Bird H, Miranda CT. Child mental health in Latin America: present and future epidemiologic research. Int J Psychiatry Med. 2003;33(3):203-22.
148. Burneo JG, Tellez-Zenteno J, Wiebe S. Understanding the burden of epilepsy in Latin America: a systematic review of its prevalence and incidence. Epilepsy Res. 2005;66(1-3):63-74.
149. Bruno E, Bartoloni A, Zammarchi L, Strohmeyer M, Bartalesi F, Bustos JA, et al. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2013;7(10):e2480.
150. Mac TL, Tran DS, Quet F, Odermatt P, Preux PM, Tan CT. Epidemiology, aetiology, and clinical management of epilepsy in Asia: a systematic review. Lancet Neurol. 2007;6(6):533-43.
151. Lengeler C. Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev. 2004(2):CD000363.
152. Nortje G, Oladeji B, Gureje O, Seedat S. Effectiveness of traditional healers in treating mental disorders: a systematic review. Lancet Psychiatry. 2016;3(2):154-70.
153. Baskind R, Birbeck G. Epilepsy care in Zambia: a study of traditional healers. Epilepsia. 2005;46(7):1121-6.
154. Kawaza K, Machen HE, Brown J, Mwanza Z, Iniguez S, Gest A, et al. Efficacy of a low-cost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi. PloS one. 2014;9(1):e86327.
References
1. World Health O. World Health Statistics. 2013. A wealth of information of global public health. 2013. http://apps.who.int/iris/bitstream/10665/82058/1/WHO_HIS_HSI_13.1_eng.pdf accessed April 2016
2. Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369(9555):60-70.
3. Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013;131(3):e755-63.
4. The World Health O. Global Health Observatory Data Repository. 2012. http://apps.who.int/ghodata/?theme=country accessed April 2016
5. Fottrell E, Osrin D, Alcock G, Azad K, Bapat U, Beard J, et al. Cause-specific neonatal mortality: analysis of 3772 neonatal deaths in Nepal, Bangladesh, Malawi and India. Arch Dis Child Fetal Neonatal Ed. 2015;100(5):F439-47.
6. Sialubanje C, Massar K, van der Pijl MS, Kirch EM, Hamer DH, Ruiter RA. Improving access to skilled facility-based delivery services: Women's beliefs on facilitators and barriers to the utilisation of maternity waiting homes in rural Zambia. Reprod Health. 2015;12:61.
7. Tshala-Katumbay D, Mwanza JC, Rohlman DS, Maestre G, Oriá RB. A global perspective on the influence of environmental exposures on the nervous system. Nature. 2015;527(7578):S187-92.
8. Sumner A. Global Poverty and the New Bottom Billion: What if Three-Quarters of the World’s Poor Live in Middle-Income Countries? Institute of Develop Studies. 2010;2010(349):41.
9. Chin-Lun Hung G, Hahn J, Alamiri B, Buka SL, Goldstein JM, Laird N, et al. Socioeconomic disadvantage and neural development from infancy through early childhood. Int J Epidemiol. 2015;44(6):1889-99.
10. Bank. W. Global Monitoring Report 2014/2015: Ending Poverty and Sharing Prosperity. 2015 [cited 2016 03/02/2016]. 1st edition:[A joint publication of the World Bank and the International Monetary Fund].
11. Lang V, Lingnau H. Defining and measuring poverty and inequality post-2015. Journal of International Development. 2015;27:15.
12. Björklund G. Workshop 4 (synthesis): securing food production under climate variability--exploring the options. Water Sci Technol. 2004;49(7):147-9.
13. Haile M. Weather patterns, food security and humanitarian response in sub-Saharan Africa. Philos Trans R Soc Lond B Biol Sci. 2005;360(1463):2169-82.
14. Kim KH, Kabir E, Ara Jahan S. A review of the consequences of global climate change on human health. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(3):299-318.
15. Rieder M, Choonara I. Armed conflict and child health. Arch Dis Child. 2012;97(1):59-62.
16. Banea M, Tylleskär T, Rosling H. Konzo and Ebola in Bandundu region of Zaire. Lancet. 1997;349(9052):621.
17. Elston JW, Moosa AJ, Moses F, Walker G, Dotta N, Waldman RJ, et al. Impact of the Ebola outbreak on health systems and population health in Sierra Leone. J Public Health (Oxf). 2015.
18. Musisi S, Kinyanda E. Emotional and behavioural disorders in HIV seropositive adolescents in urban Uganda. East African medical journal. 2009;86(1):16-24.
19. Van Rie A, Mupuala A, Dow A. Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo. Pediatrics. 2008;122(1):e123-8.
20. Scheffer IE. Epilepsy genetics revolutionizes clinical practice. Neuropediatrics. 2014;45(2):70-4.
21. Guerrant RL, DeBoer MD, Moore SR, Scharf RJ, Lima AA. The impoverished gut--a triple burden of diarrhoea, stunting and chronic disease. Nat Rev Gastroenterol Hepatol. 2013;10(4):220-9.
22. Fischer Walker CL, Lamberti L, Adair L, Guerrant RL, Lescano AG, Martorell R, et al. Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway? PLoS One. 2012;7(10):e47908.
23. Richard SA, Black RE, Gilman RH, Guerrant RL, Kang G, Lanata CF, et al. Catch-up growth occurs after diarrhea in early childhood. J Nutr. 2014;144(6):965-71.
24. Collins SM, Surette M, Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735-42.
25. Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH. Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann Neurol. 2011;69(2):240-7.
26. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451-63.
27. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-30.
28. Guerrant RL, Kosek M, Moore S, Lorntz B, Brantley R, Lima AA. Magnitude and impact of diarrheal diseases. Arch Med Res. 2002;33(4):351-5.
29. Guerrant RL, Oriá RB, Moore SR, Oriá MO, Lima AA. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev. 2008;66(9):487-505.
30. Petri WA, Miller M, Binder HJ, Levine MM, Dillingham R, Guerrant RL. Enteric infections, diarrhea, and their impact on function and development. J Clin Invest. 2008;118(4):1277-90.
31. Kisby GE, Spencer PS. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? Int J Environ Res Public Health. 2011;8(10):3889-921.
32. Marler TE, Lindström AJ. Free sugar profile in cycads. Front Plant Sci. 2014;5:526.
33. Sarmento A, Barros L, Fernandes Â, Carvalho AM, Ferreira IC. Valorization of traditional foods: nutritional and bioactive properties of Cicer arietinum L. and Lathyrus sativus L. pulses. J Sci Food Agric. 2015;95(1):179-85.
34. Spencer PS, Schaumburg HH. Lathyrism: a neurotoxic disease. Neurobehav Toxicol Teratol. 1983;5(6):625-9.
35. Tshala-Katumbay D, Mumba N, Okitundu L, Kazadi K, Banea M, Tylleskär T, et al. Cassava food toxins, konzo disease, and neurodegeneration in sub-Sahara Africans. Neurology. 2013;80(10):949-51.
36. Wang W, Feng B, Xiao J, Xia Z, Zhou X, Li P, et al. Cassava genome from a wild ancestor to cultivated varieties. Nat Commun. 2014;5:5110.
37. Banea JP, Bradbury JH, Mandombi C, Nahimana D, Denton IC, Kuwa N, et al. Effectiveness of wetting method for control of konzo and reduction of cyanide poisoning by removal of cyanogens from cassava flour. Food Nutr Bull. 2014;35(1):28-32.
38. Ciglenečki I, Eyema R, Kabanda C, Taafo F, Mekaoui H, Urbaniak V. Konzo outbreak among refugees from Central African Republic in Eastern region, Cameroon. Food Chem Toxicol. 2011;49(3):579-82.
39. Cliff J, Nicala D, Saute F, Givragy R, Azambuja G, Taela A, et al. Konzo associated with war in Mozambique. Trop Med Int Health. 1997;2(11):1068-74.
40. Nzwalo H, Cliff J. Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease. PLoS Negl Trop Dis. 2011;5(6):e1051.
41. Okitundu Luwa E-Andjafono D, Bumoko Makila-Mabe G, Ayanne MT, Kikandau JK, Mashukano N, Kazadi Kayembe T, et al. [Persistence of konzo epidemics in Kahemba, Democratic Republic of Congo: phenomenological and socio-economic aspects]. Pan Afr Med J. 2014;18:213.
42. Oluwole OS, Onabolu AO, Link H, Rosling H. Persistence of tropical ataxic neuropathy in a Nigerian community. J Neurol Neurosurg Psychiatry. 2000;69(1):96-101.
43. Tylleskär T, Légué FD, Peterson S, Kpizingui E, Stecker P. Konzo in the Central African Republic. Neurology. 1994;44(5):959-61.
44. Tekle-Haimanot R, Forsgren L, Abebe M, Gebre-Mariam A, Heijbel J, Holmgren G, et al. Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a community-based study. Epilepsy Res. 1990;7(3):230-9.
45. Ludolph AC, Hugon J, Dwivedi MP, Schaumburg HH, Spencer PS. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain. 1987;110 ( Pt 1):149-65.
46. Ngudi DD, Kuo YH, Van Montagu M, Lambein F. Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010. PLoS Negl Trop Dis. 2012;6(7):e1759.
47. Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, et al. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genet Epigenet. 2014;6:37-44.
48. Bale TL. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues Clin Neurosci. 2014;16(3):297-305.
49. Maestre G, Ottman R, Stern Y, Gurland B, Chun M, Tang MX, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol. 1995;37(2):254-9.
50. Oriá RB, Patrick PD, Oriá MO, Lorntz B, Thompson MR, Azevedo OG, et al. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz J Med Biol Res. 2010;43(3):249-56.
51. Jackson PB, Boccuto L, Skinner C, Collins JS, Neri G, Gurrieri F, et al. Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. Autism Res. 2009;2(4):232-6.
52. Peng Y, Huentelman M, Smith C, Qiu S. MET receptor tyrosine kinase as an autism genetic risk factor. Int Rev Neurobiol. 2013;113:135-65.
53. Bihaqi SW, Bahmani A, Adem A, Zawia NH. Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD. Neurotoxicology. 2014;44:114-20.
54. Collotta M, Bertazzi PA, Bollati V. Epigenetics and pesticides. Toxicology. 2013;307:35-41.
55. Dosunmu R, Alashwal H, Zawia NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech Ageing Dev. 2012;133(6):435-43.
56. Wang G, Chen Z, Bartell T, Wang X. Early Life Origins of Metabolic Syndrome: The Role of Environmental Toxicants. Curr Environ Health Rep. 2014;1(1):78-89.
57. Goodrich JM, Basu N. Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicol In Vitro. 2012;26(4):630-5.
58. Morahan JM, Yu B, Trent RJ, Pamphlett R. Genetic susceptibility to environmental toxicants in ALS. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(7):885-90.
59. Singh S, Kumar V, Singh P, Banerjee BD, Rautela RS, Grover SS, et al. Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. Mutat Res. 2012;741(1-2):101-8.
60. Boivin MJ, Okitundu D, Makila-Mabe Bumoko G, Sombo MT, Mumba D, Tylleskar T, et al. Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava. Pediatrics. 2013;131(4):e1231-9.
61. Tshala-Katumbay D, Eeg-Olofsson KE, Kazadi-Kayembe T, Tylleskär T, Fällmar P. Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation. Muscle Nerve. 2002;25(2):230-5.
62. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197-223.
63. Silberberg D, Anand NP, Michels K, Kalaria RN. Brain and other nervous system disorders across the lifespan - global challenges and opportunities. Nature. 2015;527(7578):S151-4.
64. Salomon JA, Wang H, Freeman MK, Vos T, Flaxman AD, Lopez AD, et al. Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet. 2012;380(9859):2144-62.
65. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382(9904):1575-86.
66. Chin JH, Vora N. The global burden of neurologic diseases. Neurology. 2014;83(4):349-51.
67. Organisation TWH. The 17 neglected tropical diseases. WHO; 2014 [cited 2016 02/03/2016]. 1st edition:
68. Organisation WH. World Economic Forum and World Health Organization. From burden to ‘best buys’: reducing the economic impact of non-communicable diseases in low- and middle-Income Countries. WHO; 2011 http://www.who.int/nmh/publications/best_buys_summary/en/ [cited 2016 03/02/2016].
69. Assembly WH. Global burden of epilepsy and the need for coordinated action at the country level to address its health, social and public knowledge implications. 2015. apps.who.int/gb/ebwha/pdf_files/EB136/B136_R8-en.pdf
70. John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK. Global research priorities for infections that affect the nervous system. Nature. 2015;527(7578):S178-86.
71. Fooks AR, Banyard AC, Horton DL, Johnson N, McElhinney LM, Jackson AC. Current status of rabies and prospects for elimination. Lancet. 2014;384(9951):1389-99.
72. Labeaud AD, Bashir F, King CH. Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infections. Popul Health Metr. 2011;9(1):1.
73. McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome. J Neurol Neurosurg Psychiatry. 1997;63(3):321-6.
74. RICHTER RW, SHIMOJYO S. Neurologic sequelae of Japanese B encephalitis. Neurology. 1961;11:553-9.
75. Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The "silent" global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013;26(1):86-102.
76. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.
77. Robin S, Ramful D, Le Seach' F, Jaffar-Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric chikungunya infection. J Child Neurol. 2008;23(9):1028-35.
78. Al-Qahtani AA, Nazir N, Al-Anazi MR, Rubino S, Al-Ahdal MN. Zika virus: a new pandemic threat. J Infect Dev Ctries. 2016;10(3):201-7.
79. Chang C, Ortiz K, Ansari A, Gershwin ME. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13.
80. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. 2016.
81. Fleming-Dutra KE, Nelson JM, Fischer M, Staples JE, Karwowski MP, Mead P, et al. Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection — United States, February 2016. Center for Disease Control and Prevention; 2016 [cited 2016 15/04/2016]. Available from: http://www.cdc.gov/mmwr/volumes/65/wr/mm6507e1.htm.
82. UNAIDS. How AIDS changed everything — MDG6: 15 years, 15 lessons of hope from the AIDS
response. 2015 [cited 2016 15/04/2016]. Available from: http://www.unaids.org/en/resources/documents/2015/MDG6_15years-15lessonsfromtheAIDSresponse.
83. Tan IL, Smith BR, von Geldern G, Mateen FJ, McArthur JC. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11(7):605-17.
84. Abubakar A, Holding P, Newton CR, van Baar A, van de Vijver FJ. The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. Developmental medicine and child neurology. 2009;51(12):968-73.
85. Wilmshurst JM, Donald KA, Eley B. Update on the key developments of the neurologic complications in children infected with HIV. Current opinion in HIV and AIDS. 2014;9(6):533-8.
86. Seale AC, Blencowe H, Zaidi A, Ganatra H, Syed S, Engmann C, et al. Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res. 2013;74 Suppl 1:73-85.
87. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatr. 2010;10:39.
88. Mehar V, Yadav D, Somani P, Bhatambare G, Mulye S, Singh K. Neonatal sepsis in a tertiary care center in central India: microbiological profile, antimicrobial sensitivity pattern and outcome. J Neonatal Perinatal Med. 2013;6(2):165-72.
89. Thwaites GE, van Toorn R, Schoeman J. Tuberculous meningitis: more questions, still too few answers. Lancet Neurol. 2013;12(10):999-1010.
90. Organization. scWH, Research. DoRHa. Global incidence and prevalence of selected curable sexually transmitted infections – 2008. 2012.
91. Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, et al. Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children. JAMA. 2007;297(20):2232-40.
92. Kihara M, Carter JA, Newton CR. The effect of Plasmodium falciparum on cognition: a systematic review. Trop Med Int Health. 2006;11(4):386-97.
93. Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K, et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet neurology. 2013.
94. Fleury A, Gomez T, Alvarez I, Meza D, Huerta M, Chavarria A, et al. High prevalence of calcified silent neurocysticercosis in a rural village of Mexico. Neuroepidemiology. 2003;22(2):139-45.
95. Ferrari TC, Moreira PR. Neuroschistosomiasis: clinical symptoms and pathogenesis. Lancet Neurol. 2011;10(9):853-64.
96. Kvalsvig J, Albonico M. Effects of geohelminth infections on neurological development. Handb Clin Neurol. 2013;114:369-79.
97. Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527(7578):S193-7.
98. Murgio A, Fernandez Milà J, Manolio A, Maurel D, Ubeda C. Minor head injury at paediatric age in Argentina. J Neurosurg Sci. 1999;43(1):15-23; discussion -4.
99. Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg. 2000;93(4):546-9.
100. Jiang JY, Xu W, Li WP, Gao GY, Bao YH, Liang YM, et al. Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. J Cereb Blood Flow Metab. 2006;26(6):771-6.
101. Liu WG, Qiu WS, Zhang Y, Wang WM, Lu F, Yang XF. Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. J Int Med Res. 2006;34(1):58-64.
102. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, et al. A year-long caregiver training program improves cognition in preschool Ugandan children with human immunodeficiency virus. J Pediatr. 2013;163(5):1409-16.e1-5.
103. Engle PL, Fernald LC, Alderman H, Behrman J, O'Gara C, Yousafzai A, et al. Strategies for reducing inequalities and improving developmental outcomes for young children in low-income and middle-income countries. Lancet. 2011;378(9799):1339-53.
104. Bangirana P, Giordani B, John CC, Page C, Opoka RO, Boivin MJ. Immediate neuropsychological and behavioral benefits of computerized cognitive rehabilitation in Ugandan pediatric cerebral malaria survivors. J Dev Behav Pediatr. 2009;30(4):310-8.
105. Boivin MJ, Busman RA, Parikh SM, Bangirana P, Page CF, Opoka RO, et al. A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV. Neuropsychology. 2010;24(5):667-73.
106. Cottler LB, Zunt J, Weiss B, Kamal AK, Vaddiparti K. Building global capacity for brain and nervous system disorders research. Nature. 2015;527(7578):S207-13.
107. Kasper J, Bajunirwe F. Brain drain in sub-Saharan Africa: contributing factors, potential remedies and the role of academic medical centres. Archives of Disease in Childhood. 2012;97(11):973-9.
108. World Health O. World health report 2006 – working together for health. 2006.
109. Department of Human Resources for Health WHO. Spotlight on health workforce statistics: Establishing and monitoring benchmarks for human resources for health:the workforce density approach. 2008.
110. Unicef. Statistics and Monitoring. 2004.
111. Wilmshurst JM, Morrow B, du Preez A, Githanga D, Kennedy N, Zar HJ. The African Pediatric Fellowship Program: Training in Africa for Africans. Pediatrics. 2016;137(1):1-12.
112. Mandeville KL, Ulaya G, Lagarde M, Gwesele L, Dzowela T, Hanson K, et al. Early career retention of Malawian medical graduates: a retrospective cohort study. Tropical medicine & international health : TM & IH. 2015;20(1):106-14.
113. Davidson LL, Grigorenko EL, Boivin MJ, Rapa E, Stein A. A focus on adolescence to reduce neurological, mental health and substance-use disability. Nature. 2015;527(7578):S161-6.
114. Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, et al. Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet. 2011;377(9783):2093-102.
115. Bank W. World Development Report 2007. Development and the Next Generation. Washington DC: 2006.
116. UNICEF. The State of the World's Children.
117. UNICEF. Ending Child Marriage: Progress and Prospects. 2012.
118. Grigorenko EL, et al. Culture and competence: Contexts of life success. Washington, DC: American Psychological Association; 2004. p. 23-53.
119. Reed RV, Fazel M, Jones L, Panter-Brick C, Stein A. Mental health of displaced and refugee children resettled in low-income and middle-income countries: risk and protective factors. Lancet. 2012;379(9812):250-65.
120. Tyrer RA, Fazel M. School and community-based interventions for refugee and asylum seeking children: a systematic review. PLoS One. 2014;9(2):e89359.
121. Ehlers CL, Criado JR. Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? Alcohol. 2010;44(1):27-37.
122. Matthews DB. Adolescence and alcohol: recent advances in understanding the impact of alcohol use during a critical developmental window. Alcohol. 2010;44(1):1-2.
123. Bhana A, Mellins CA, Petersen I, Alicea S, Myeza N, Holst H, et al. The VUKA family program: piloting a family-based psychosocial intervention to promote health and mental health among HIV infected early adolescents in South Africa. AIDS Care. 2014;26(1):1-11.
124. Ravindranath V, Dang HM, Goya RG, Mansour H, Nimgaonkar VL, Russell VA, et al. Regional research priorities in brain and nervous system disorders. Nature. 2015;527(7578):S198-206.
125. Kerac M, Postels DG, Mallewa M, Alusine Jalloh A, Voskuijl WP, Groce N, et al. The interaction of malnutrition and neurologic disability in Africa. Semin Pediatr Neurol. 2014;21(1):42-9.
126. Degenhardt L, Whiteford H, Hall WD. The Global Burden of Disease projects: what have we learned about illicit drug use and dependence and their contribution to the global burden of disease? Drug Alcohol Rev. 2014;33(1):4-12.
127. Hess AT, Jacobson SW, Jacobson JL, Molteno CD, van der Kouwe AJ, Meintjes EM. A comparison of spectral quality in magnetic resonance spectroscopy data acquired with and without a novel EPI-navigated PRESS sequence in school-aged children with fetal alcohol spectrum disorders. Metab Brain Dis. 2014;29(2):323-32.
128. Kwiatkowski MA, Roos A, Stein DJ, Thomas KG, Donald K. Effects of prenatal methamphetamine exposure: a review of cognitive and neuroimaging studies. Metab Brain Dis. 2014;29(2):245-54.
129. Ba-Diop A, Marin B, Druet-Cabanac M, Ngoungou EB, Newton CR, Preux PM. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13(10):1029-44.
130. Mustapha AF, Preux PM, Sanya EO, Akinleye CA. The prevalence and subjective handicap of epilepsy in Ilie--a rural riverine community in South West Nigeria: a door-to-door survey. Epilepsy Behav. 2014;37:258-64.
131. Osakwe C, Otte WM, Alo C. Epilepsy prevalence, potential causes and social beliefs in Ebonyi State and Benue State, Nigeria. Epilepsy Res. 2014;108(2):316-26.
132. Wagner RG, Ngugi AK, Twine R, Bottomley C, Kamuyu G, Gómez-Olivé FX, et al. Prevalence and risk factors for active convulsive epilepsy in rural northeast South Africa. Epilepsy Res. 2014;108(4):782-91.
133. Wilmshurst JM, Birbeck GL, Newton CR. Epilepsy is ubiquitous, but more devastating in the poorer regions of the world... or is it? Epilepsia. 2014.
134. Sepúlveda J, Murray C. The state of global health in 2014. Science. 2014;345(6202):1275-8.
135. Laughton B, Cornell M, Boivin M, Van Rie A. Neurodevelopment in perinatally HIV-infected children: a concern for adolescence. Journal of the International AIDS Society. 2013;16:18603.
136. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197-223.
137. Hoare J, Ransford GL, Phillips N, Amos T, Donald K, Stein DJ. Systematic review of neuroimaging studies in vertically transmitted HIV positive children and adolescents. Metabolic brain disease. 2014;29(2):221-9.
138. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10(11):e1001547.
139. Alhasnawi S, Sadik S, Rasheed M, Baban A, Al-Alak MM, Othman AY, et al. The prevalence and correlates of DSM-IV disorders in the Iraq Mental Health Survey (IMHS). World Psychiatry. 2009;8(2):97-109.
140. Espié E, Gaboulaud V, Baubet T, Casas G, Mouchenik Y, Yun O, et al. Trauma-related psychological disorders among Palestinian children and adults in Gaza and West Bank, 2005-2008. Int J Ment Health Syst. 2009;3(1):21.
141. Al-Gazali L, Hamamy H. Consanguinity and dysmorphology in Arabs. Hum Hered. 2014;77(1-4):93-107.
142. Al-Gazali L, Hamamy H, Al-Arrayad S. Genetic disorders in the Arab world. BMJ. 2006;333(7573):831-4.
143. Tadmouri GO, Al Ali MT, Al-Haj Ali S, Al Khaja N. CTGA: the database for genetic disorders in Arab populations. Nucleic Acids Res. 2006;34(Database issue):D602-6.
144. Hamdi E, Gawad T, Khoweiled A, Sidrak AE, Amer D, Mamdouh R, et al. Lifetime prevalence of alcohol and substance use in Egypt: a community survey. Subst Abus. 2013;34(2):97-104.
145. Collaborators GBoDS. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743-800.
146. Fleitlich-Bilyk B, Goodman R. Prevalence of child and adolescent psychiatric disorders in southeast Brazil. J Am Acad Child Adolesc Psychiatry. 2004;43(6):727-34.
147. Duarte C, Hoven C, Berganza C, Bordin I, Bird H, Miranda CT. Child mental health in Latin America: present and future epidemiologic research. Int J Psychiatry Med. 2003;33(3):203-22.
148. Burneo JG, Tellez-Zenteno J, Wiebe S. Understanding the burden of epilepsy in Latin America: a systematic review of its prevalence and incidence. Epilepsy Res. 2005;66(1-3):63-74.
149. Bruno E, Bartoloni A, Zammarchi L, Strohmeyer M, Bartalesi F, Bustos JA, et al. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2013;7(10):e2480.
150. Mac TL, Tran DS, Quet F, Odermatt P, Preux PM, Tan CT. Epidemiology, aetiology, and clinical management of epilepsy in Asia: a systematic review. Lancet Neurol. 2007;6(6):533-43.
151. Lengeler C. Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev. 2004(2):CD000363.
152. Nortje G, Oladeji B, Gureje O, Seedat S. Effectiveness of traditional healers in treating mental disorders: a systematic review. Lancet Psychiatry. 2016;3(2):154-70.
153. Baskind R, Birbeck G. Epilepsy care in Zambia: a study of traditional healers. Epilepsia. 2005;46(7):1121-6.
154. Kawaza K, Machen HE, Brown J, Mwanza Z, Iniguez S, Gest A, et al. Efficacy of a low-cost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi. PloS one. 2014;9(1):e86327.