@article{Espeche_2020, title={Benign Non-Familial Neonatal Seizure: A study of 40 Argentinian patients}, volume={1}, url={https://jicna.org/index.php/journal/article/view/139}, DOI={10.17724/jicna.2020.139}, abstractNote={<p>Background: Benign non-familial neonatal seizures (BNFNS) represent a recognized epileptic syndrome that is heterogeneous in its presentation. The objective of this study was to analyze age of onset, electroclinical characteristics, treatment, and progress of patients diagnosed with BNFNS.<br />Methods: Retrospective study of 40 cases that met inclusion criteria for BNFNS from July 1996 to February 2016.<br />Results: 40 patients (21 female, 19 male) were examined, with a follow-up of 1 year and 10 months up to 16 years of age. Age of onset: 1–7 days, 30/40 (75%); 8–20 days, 10/40 (25%); mean: 6 days; median: 3.5 days. All patients presented focal clonic seizures (unifocal or alternating; isolated or clustered), and four of them evolved into status epilepticus. Interictal electroencephalogram (EEG) was normal in 37 cases; three showed sharp focal or multifocal waves. An ictal EEG was performed in a patient and initial spike-wave activity was noted in temporal area, which quickly spread to the homologous hemisphere. Phenobarbital was the initial drug in all infants; 10/40 cases required combination with carbamazepine. In their evolution, two patients with a history of status presented intellectual disability; seven children had afebrile seizures in the first year of life; and two patients evolved into focal epilepsy in childhood. Of all the patients, 95% are seizure-free at the moment and do not receive antiepileptic treatment.<br />Conclusions: In infants with clonic focal seizures, with no history of relevance and normal complementary tests, BNFNS should be considered. Although the majority of . patients evolved favorably, some presented epilepsy and intellectual disability during their follow-up.</p>}, number={1}, journal={Journal of the International Child Neurology Association}, author={Espeche, Alberto Luis}, year={2020}, month={Jun.} }