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Submitted
March 10, 2020
Accepted
June 17, 2021
Published
March 13, 2022
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Abstract
ABSTRACT
Background
Sydenham Chorea remains a common disease entity in developing countries. There is a need for a structured treatment protocol and adequate follow up in these countries.
Methods
In this study 23 patients form the Maputo Central Hospitals (MCH), and diagnosed with Sydenham Chorea, were treated with a standardized protocol (penicillin and prednisone in the acute phase and monthly benzathine penicillin in the follow up).
Results
With this treatment protocol 82 % of patients became symptom free. In 4 a recurrence was seen during follow up and this could be explained by low treatment compliance during the follow up.
Conclusions
With a standard treatment protocol, the majority of patients are cured. To avoid recurrences of SC, better follow up program should be advocated.
Keywords
sydenham chorea
antistreptolysin O
jones criteria
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
How to Cite
Wale, C., GN, S., Sulemane, D., & Lagae, L. (2022). Treatment of Sydenham Chorea in Mozambique. Journal of the International Child Neurology Association, 1(1). https://doi.org/10.17724/jicna.2022.187
References
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1. Cardoso F: Sydenham´s Chorea. Current Treatment Options in Neurology. 2008, 10:230-235.
2. Gurkas E, Karolok ZS, Taskin BD, Aydogmus U, Guven Alev, Degerlyurt A, Bektas O, Yilmaz C: Predictors of recurrence in Sydenham´s chorea: Clinical observation from a single center. Journal of Brain & Development. 2016, 38 (9): 827-34.
3. Walker KG, Vries PJ, Stein D, Wilmshurt JM: Sydenhams Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Managements in Resource-poor Countries. Journal of Child Neurology. 2015, 30(7): 850-859.
4. Nelson Textbook of pediatrics 18th Edition, Chapter 597.2 pg 2496 (in Portuguese)
5. Berrios X, Quesney F, Morales A, Blazquez J, BisnoAL: Are all recurrences of ``pure´´ Sydenham chorea true recurrences of acute rheumatic fever? Journal of Pediatrics. 1985,107:867-872.
6. Garvey MA, Snider LA, Leitman SF, Werden R, Swedo SE: Treatment of Sydenham´s Chorea with intravenous Immunoglobulin, plasma exchange, or Prednison. Journal of Child Neurology. 2005,20:424-429.
7. Aicardi: Diseases of the nervous system in childhood. 4th edition, pg 1041
8. Donald. L. Gilbert: Sydenham Chorea: UpToDate. Oct25, 2018
9. Paz J. A. Silva CAA, Marques-Dias MJ: Randomized double-blind study with Prednisone in Sydenham´s Chorea. Journal of Pediatric Neurology. 2006, 34(4):264-9.
10. Walker AR, Tani LY, Thomposon A: Rheumatic Chorea: Relationship to Systemic Manifestation and Response to Corticosteroids. Journal of Pediatrics. 2007,151(6):679-83.
11. Al-Eissa A: Sydenham´s Chorea: a new look at an old disease. The British Journal of Clinical Pratice. 1993, 47(1):14-16.
12. Dean SL, Singer HS: Treatment of Sydenham´s Chorea: A review of the Current Evidence. Tremor and Other Hyperkinetic Movements. 2017,1(7):456.
13. Walker KG, Wilmshurst JM: An uptade on the treatment of Sydenha´s Chorea: the evidence for established and evolving interventions. Therapeutic Advances in Neurology Disorders. 2010,3(5):301-309.
14. Oosterveer DM, Overwe-Plandsoen WCT, Roos RAC: Sydenham´sChorea: A pratical overview of the current literature. Pediatric neurology. 2010,43(1):1-6.
15. Demiroren K, Yuvuz H, Cam L, Oran B, Karaaslan S, Demiroren S: Sudenham´s Chorea: A Clinical Follow-Up of 65 patients. Journal of Child Neurology. 2007;22(5):550-554.
16. Bonthius DJ, Karacay B: Sudenham´s chorea: not gone and not forgotten. Seminars in Pediatric Neurology. 2003,10(1):11-19.
17. Gebremariam A: Sudenham´s chorea: risk factors and the role of prophylactic benzathine penicillin G in preventing recurrence. Annals of Tropical Paediatrics. 1999,19:161-165.
18. Barash J, Margalith Dov, Matitiau Abraham: Corticosteroid Treatment in Patients with Sydenham´s Chorea. Pediatric Neurology. 2005, 32(3):205-7 .
References
1. Cardoso F: Sydenham´s Chorea. Current Treatment Options in Neurology. 2008, 10:230-235.
2. Gurkas E, Karolok ZS, Taskin BD, Aydogmus U, Guven Alev, Degerlyurt A, Bektas O, Yilmaz C: Predictors of recurrence in Sydenham´s chorea: Clinical observation from a single center. Journal of Brain & Development. 2016, 38 (9): 827-34.
3. Walker KG, Vries PJ, Stein D, Wilmshurt JM: Sydenhams Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Managements in Resource-poor Countries. Journal of Child Neurology. 2015, 30(7): 850-859.
4. Nelson Textbook of pediatrics 18th Edition, Chapter 597.2 pg 2496 (in Portuguese)
5. Berrios X, Quesney F, Morales A, Blazquez J, BisnoAL: Are all recurrences of ``pure´´ Sydenham chorea true recurrences of acute rheumatic fever? Journal of Pediatrics. 1985,107:867-872.
6. Garvey MA, Snider LA, Leitman SF, Werden R, Swedo SE: Treatment of Sydenham´s Chorea with intravenous Immunoglobulin, plasma exchange, or Prednison. Journal of Child Neurology. 2005,20:424-429.
7. Aicardi: Diseases of the nervous system in childhood. 4th edition, pg 1041
8. Donald. L. Gilbert: Sydenham Chorea: UpToDate. Oct25, 2018
9. Paz J. A. Silva CAA, Marques-Dias MJ: Randomized double-blind study with Prednisone in Sydenham´s Chorea. Journal of Pediatric Neurology. 2006, 34(4):264-9.
10. Walker AR, Tani LY, Thomposon A: Rheumatic Chorea: Relationship to Systemic Manifestation and Response to Corticosteroids. Journal of Pediatrics. 2007,151(6):679-83.
11. Al-Eissa A: Sydenham´s Chorea: a new look at an old disease. The British Journal of Clinical Pratice. 1993, 47(1):14-16.
12. Dean SL, Singer HS: Treatment of Sydenham´s Chorea: A review of the Current Evidence. Tremor and Other Hyperkinetic Movements. 2017,1(7):456.
13. Walker KG, Wilmshurst JM: An uptade on the treatment of Sydenha´s Chorea: the evidence for established and evolving interventions. Therapeutic Advances in Neurology Disorders. 2010,3(5):301-309.
14. Oosterveer DM, Overwe-Plandsoen WCT, Roos RAC: Sydenham´sChorea: A pratical overview of the current literature. Pediatric neurology. 2010,43(1):1-6.
15. Demiroren K, Yuvuz H, Cam L, Oran B, Karaaslan S, Demiroren S: Sudenham´s Chorea: A Clinical Follow-Up of 65 patients. Journal of Child Neurology. 2007;22(5):550-554.
16. Bonthius DJ, Karacay B: Sudenham´s chorea: not gone and not forgotten. Seminars in Pediatric Neurology. 2003,10(1):11-19.
17. Gebremariam A: Sudenham´s chorea: risk factors and the role of prophylactic benzathine penicillin G in preventing recurrence. Annals of Tropical Paediatrics. 1999,19:161-165.
18. Barash J, Margalith Dov, Matitiau Abraham: Corticosteroid Treatment in Patients with Sydenham´s Chorea. Pediatric Neurology. 2005, 32(3):205-7 .
2. Gurkas E, Karolok ZS, Taskin BD, Aydogmus U, Guven Alev, Degerlyurt A, Bektas O, Yilmaz C: Predictors of recurrence in Sydenham´s chorea: Clinical observation from a single center. Journal of Brain & Development. 2016, 38 (9): 827-34.
3. Walker KG, Vries PJ, Stein D, Wilmshurt JM: Sydenhams Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Managements in Resource-poor Countries. Journal of Child Neurology. 2015, 30(7): 850-859.
4. Nelson Textbook of pediatrics 18th Edition, Chapter 597.2 pg 2496 (in Portuguese)
5. Berrios X, Quesney F, Morales A, Blazquez J, BisnoAL: Are all recurrences of ``pure´´ Sydenham chorea true recurrences of acute rheumatic fever? Journal of Pediatrics. 1985,107:867-872.
6. Garvey MA, Snider LA, Leitman SF, Werden R, Swedo SE: Treatment of Sydenham´s Chorea with intravenous Immunoglobulin, plasma exchange, or Prednison. Journal of Child Neurology. 2005,20:424-429.
7. Aicardi: Diseases of the nervous system in childhood. 4th edition, pg 1041
8. Donald. L. Gilbert: Sydenham Chorea: UpToDate. Oct25, 2018
9. Paz J. A. Silva CAA, Marques-Dias MJ: Randomized double-blind study with Prednisone in Sydenham´s Chorea. Journal of Pediatric Neurology. 2006, 34(4):264-9.
10. Walker AR, Tani LY, Thomposon A: Rheumatic Chorea: Relationship to Systemic Manifestation and Response to Corticosteroids. Journal of Pediatrics. 2007,151(6):679-83.
11. Al-Eissa A: Sydenham´s Chorea: a new look at an old disease. The British Journal of Clinical Pratice. 1993, 47(1):14-16.
12. Dean SL, Singer HS: Treatment of Sydenham´s Chorea: A review of the Current Evidence. Tremor and Other Hyperkinetic Movements. 2017,1(7):456.
13. Walker KG, Wilmshurst JM: An uptade on the treatment of Sydenha´s Chorea: the evidence for established and evolving interventions. Therapeutic Advances in Neurology Disorders. 2010,3(5):301-309.
14. Oosterveer DM, Overwe-Plandsoen WCT, Roos RAC: Sydenham´sChorea: A pratical overview of the current literature. Pediatric neurology. 2010,43(1):1-6.
15. Demiroren K, Yuvuz H, Cam L, Oran B, Karaaslan S, Demiroren S: Sudenham´s Chorea: A Clinical Follow-Up of 65 patients. Journal of Child Neurology. 2007;22(5):550-554.
16. Bonthius DJ, Karacay B: Sudenham´s chorea: not gone and not forgotten. Seminars in Pediatric Neurology. 2003,10(1):11-19.
17. Gebremariam A: Sudenham´s chorea: risk factors and the role of prophylactic benzathine penicillin G in preventing recurrence. Annals of Tropical Paediatrics. 1999,19:161-165.
18. Barash J, Margalith Dov, Matitiau Abraham: Corticosteroid Treatment in Patients with Sydenham´s Chorea. Pediatric Neurology. 2005, 32(3):205-7 .