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Abstract
ABSTRACT
Background
Sydenham Chorea remains a common disease entity in developing countries. There is a need for a structured treatment protocol and adequate follow up in these countries.
Methods
In this study 23 patients form the Maputo Central Hospitals (MCH), and diagnosed with Sydenham Chorea, were treated with a standardized protocol (penicillin and prednisone in the acute phase and monthly benzathine penicillin in the follow up).
Results
With this treatment protocol 82 % of patients became symptom free. In 4 a recurrence was seen during follow up and this could be explained by low treatment compliance during the follow up.
Conclusions
With a standard treatment protocol, the majority of patients are cured. To avoid recurrences of SC, better follow up program should be advocated.
Keywords
Article Details
Copyright (c) 2022 Carla Wale, Silva GN, Dalila Sulemane, Lieven Lagae
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References
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1. Cardoso F: Sydenham´s Chorea. Current Treatment Options in Neurology. 2008, 10:230-235.
2. Gurkas E, Karolok ZS, Taskin BD, Aydogmus U, Guven Alev, Degerlyurt A, Bektas O, Yilmaz C: Predictors of recurrence in Sydenham´s chorea: Clinical observation from a single center. Journal of Brain & Development. 2016, 38 (9): 827-34.
3. Walker KG, Vries PJ, Stein D, Wilmshurt JM: Sydenhams Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Managements in Resource-poor Countries. Journal of Child Neurology. 2015, 30(7): 850-859.
4. Nelson Textbook of pediatrics 18th Edition, Chapter 597.2 pg 2496 (in Portuguese)
5. Berrios X, Quesney F, Morales A, Blazquez J, BisnoAL: Are all recurrences of ``pure´´ Sydenham chorea true recurrences of acute rheumatic fever? Journal of Pediatrics. 1985,107:867-872.
6. Garvey MA, Snider LA, Leitman SF, Werden R, Swedo SE: Treatment of Sydenham´s Chorea with intravenous Immunoglobulin, plasma exchange, or Prednison. Journal of Child Neurology. 2005,20:424-429.
7. Aicardi: Diseases of the nervous system in childhood. 4th edition, pg 1041
8. Donald. L. Gilbert: Sydenham Chorea: UpToDate. Oct25, 2018
9. Paz J. A. Silva CAA, Marques-Dias MJ: Randomized double-blind study with Prednisone in Sydenham´s Chorea. Journal of Pediatric Neurology. 2006, 34(4):264-9.
10. Walker AR, Tani LY, Thomposon A: Rheumatic Chorea: Relationship to Systemic Manifestation and Response to Corticosteroids. Journal of Pediatrics. 2007,151(6):679-83.
11. Al-Eissa A: Sydenham´s Chorea: a new look at an old disease. The British Journal of Clinical Pratice. 1993, 47(1):14-16.
12. Dean SL, Singer HS: Treatment of Sydenham´s Chorea: A review of the Current Evidence. Tremor and Other Hyperkinetic Movements. 2017,1(7):456.
13. Walker KG, Wilmshurst JM: An uptade on the treatment of Sydenha´s Chorea: the evidence for established and evolving interventions. Therapeutic Advances in Neurology Disorders. 2010,3(5):301-309.
14. Oosterveer DM, Overwe-Plandsoen WCT, Roos RAC: Sydenham´sChorea: A pratical overview of the current literature. Pediatric neurology. 2010,43(1):1-6.
15. Demiroren K, Yuvuz H, Cam L, Oran B, Karaaslan S, Demiroren S: Sudenham´s Chorea: A Clinical Follow-Up of 65 patients. Journal of Child Neurology. 2007;22(5):550-554.
16. Bonthius DJ, Karacay B: Sudenham´s chorea: not gone and not forgotten. Seminars in Pediatric Neurology. 2003,10(1):11-19.
17. Gebremariam A: Sudenham´s chorea: risk factors and the role of prophylactic benzathine penicillin G in preventing recurrence. Annals of Tropical Paediatrics. 1999,19:161-165.
18. Barash J, Margalith Dov, Matitiau Abraham: Corticosteroid Treatment in Patients with Sydenham´s Chorea. Pediatric Neurology. 2005, 32(3):205-7 .
References
2. Gurkas E, Karolok ZS, Taskin BD, Aydogmus U, Guven Alev, Degerlyurt A, Bektas O, Yilmaz C: Predictors of recurrence in Sydenham´s chorea: Clinical observation from a single center. Journal of Brain & Development. 2016, 38 (9): 827-34.
3. Walker KG, Vries PJ, Stein D, Wilmshurt JM: Sydenhams Chorea and PANDAS in South Africa: Review of Evidence and Recommendations for Managements in Resource-poor Countries. Journal of Child Neurology. 2015, 30(7): 850-859.
4. Nelson Textbook of pediatrics 18th Edition, Chapter 597.2 pg 2496 (in Portuguese)
5. Berrios X, Quesney F, Morales A, Blazquez J, BisnoAL: Are all recurrences of ``pure´´ Sydenham chorea true recurrences of acute rheumatic fever? Journal of Pediatrics. 1985,107:867-872.
6. Garvey MA, Snider LA, Leitman SF, Werden R, Swedo SE: Treatment of Sydenham´s Chorea with intravenous Immunoglobulin, plasma exchange, or Prednison. Journal of Child Neurology. 2005,20:424-429.
7. Aicardi: Diseases of the nervous system in childhood. 4th edition, pg 1041
8. Donald. L. Gilbert: Sydenham Chorea: UpToDate. Oct25, 2018
9. Paz J. A. Silva CAA, Marques-Dias MJ: Randomized double-blind study with Prednisone in Sydenham´s Chorea. Journal of Pediatric Neurology. 2006, 34(4):264-9.
10. Walker AR, Tani LY, Thomposon A: Rheumatic Chorea: Relationship to Systemic Manifestation and Response to Corticosteroids. Journal of Pediatrics. 2007,151(6):679-83.
11. Al-Eissa A: Sydenham´s Chorea: a new look at an old disease. The British Journal of Clinical Pratice. 1993, 47(1):14-16.
12. Dean SL, Singer HS: Treatment of Sydenham´s Chorea: A review of the Current Evidence. Tremor and Other Hyperkinetic Movements. 2017,1(7):456.
13. Walker KG, Wilmshurst JM: An uptade on the treatment of Sydenha´s Chorea: the evidence for established and evolving interventions. Therapeutic Advances in Neurology Disorders. 2010,3(5):301-309.
14. Oosterveer DM, Overwe-Plandsoen WCT, Roos RAC: Sydenham´sChorea: A pratical overview of the current literature. Pediatric neurology. 2010,43(1):1-6.
15. Demiroren K, Yuvuz H, Cam L, Oran B, Karaaslan S, Demiroren S: Sudenham´s Chorea: A Clinical Follow-Up of 65 patients. Journal of Child Neurology. 2007;22(5):550-554.
16. Bonthius DJ, Karacay B: Sudenham´s chorea: not gone and not forgotten. Seminars in Pediatric Neurology. 2003,10(1):11-19.
17. Gebremariam A: Sudenham´s chorea: risk factors and the role of prophylactic benzathine penicillin G in preventing recurrence. Annals of Tropical Paediatrics. 1999,19:161-165.
18. Barash J, Margalith Dov, Matitiau Abraham: Corticosteroid Treatment in Patients with Sydenham´s Chorea. Pediatric Neurology. 2005, 32(3):205-7 .